A Reproductive Lexicon


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tumor necrosis factor

Tumor necrosis factors (TNFs) are a family of cytokines (signal molecules) which signal by binding to two specific receptors, TNF-receptor type I and TNF-receptor type II. Activation of the TNF signaling pathway controls cell survival, death, proliferation, and differentiation. This pathway, therefore, is responsible for the development, organization, and homeostasis of many tissues, including the breast and brain/nervous system.

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